I clean all my pump parts with a bottle brush and hot soapy water after each use. I then put everything into my counter top sterilizer. Pretty well 3 sets of parts and 4 bottles can fit in all at one time, so it's not really a big deal/job - having extra sets to use helps alot with cleaning stress!
As for sterilizing, some do it often, others don't. My doc recommends things be sterilized until about 4 months of age or so...or once your LO starts to put more in his/her mouth anyway. I've also considered all that's going around this fall and feel more confident making sure everything is cleaned really well.
I generally tell when membranes have done their job based on feel since they tend to feel thinner and are more flexible once they have been used for a bit. Usually by 2 months they are good for a change, but this also changes with the # of sessions. I currently pump 7x's a day and have been doing so for about 6 weeks now and have noticed that mine are now getting pretty thin (I have 3 sets of them I use daily though). I believe Medela suggests every 3 months, but that is more likely for part time pumpers, not constant use.

CL of the Exclusively Pumping Board
Proud Retired EP'er for Parker!
Currently EP'ing for Abigail!

