My sexual life and regular life have changed significantly over the years. I think that the two are interconnected, so whatever is going on with me emotionally, mentally, physically, etc., also changes my sexual life.
The first time was during my first marriage, when we eventually stopped having sex altogether. Either he was never home (because he was too busy running around with his drinking/drug buddies or in prison) or because I was so angry at him or afraid of him that I simply could not have sex with him. In a sense, it was a relief not to have sex with him, because our sex life was never that good to begin with, so that was another stressor that I didn't need to have to deal with.
When I met Master my sex life change dramatically and for the better, because I was finally through with vanilla sex and could have the kinky sex that I needed and craved. O/our sex life has changed quite a bit since then because of my illnesses. Master has always known me when I was chronically ill, but that fact didn't really get in the way until last spring when I was diagnosed with hypothyroidism and my libido took a nose dive and disappeared. It's been a struggle getting it but Master has never given up on me. Living with five chronic illnesses day in and out isn't easy, but W/we've learned to deal with it. There have also been some states of depression that I've gone through when I haven't felt sexually connected to Him. In short, my mental, emotional and physical well-being is connected to my sexual well-being.